Structure of inhibitor-bound human PSS1

Structure of inhibitor-bound human PSS1 Descriptor: (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, (7P)-7-[(4S)-4-{4-[3,5-bis(trifluoromethyl)phenoxy]phenyl}-5-(2,2-difluoropropyl)-6-oxo-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-1,3-benzoxazol-2(3H)-one, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, ... Authors: Long, T, Li, X. Deposit date: 2024-03-20 Release date: 2024-09-04 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.87 Å) Cite: Molecular insights into human phosphatidylserine synthase 1 reveal its inhibition promotes LDL uptake. Cell, 187, 2024