Multi-omics linkage analysis for the striatopallidal (<i>Drd1</i>) and the striatopallidal (<i>Drd2</i>) neurons from huamn striatum

multi-omic snATAC-/snRNA-seq dataset from the striatum region of the brain. Striata were collected from eight genetically diverse inbred mouse strains, representing the founders of the Diversity Outbred (DO) and Collaborative Cross populations used for genetic analysis of complex traits.<br><b>Methods</b>Enhlink analyses were performed independently using snATAC-seq alone, and either separating Drd1 and drd2 cells into two clusters or by combining both neurons together and using the Drd1/2 status as covariates (combined analysis). The analysis was repeated to correlate peak activity with the gene expression matrix from the snRNA-seq. Then common peaks between the modalities were then identified.<b>File Description</b>Each BEDPE file contains genomic links using the 6 first columns to define the enhancer (three first columns) and the promoter (the following three columns). Also, each file refers to a specific cell type written in the file name. The <i>drd</i> extension in the file name designates the combined analyses and the merged extension designates the merged analyses<b>Software</b>https://gitlab.com/Grouumf/enhlinktools<b>Citation</b>https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03374-9