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ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11

NIAID Data Ecosystem2026-05-02 收录

DNA损伤修复

蛋白质复合物结构

数据链接：

https://www.rcsb.org/structure/5DA9 数据链接链接失效反馈

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资源简介：

ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11

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创建时间：

2024-10-09

蛋白质复合物结构

HSP90热休克蛋白90

Crystal structure of the human RPAP3(TPR2)-PIH1D1(CS) complex Descriptor: CALCIUM ION, PIH1 domain-containing protein 1, RNA polymerase II-associated protein 3 Authors: Henri, J, Quinternet, M, Maniva

Protein Data Bank Japan2024-01-17 更新50

Data and code for analyzing DSB mobility

DNA损伤修复

肌动蛋白动力学

Double-strand breaks (DSBs) are critical lesions in genomic DNA, and their accurate repair is essential for maintaining genome stability. The nuclear actin cytoskeleton has been implicated in homology

DataCite Commons2025-10-22 更新40

mRNA-seq for etoposide-treated TLP-knockdown cells

基因表达调控

DNA损伤修复

We explored the mechanism by which TLP affects DNA damage response. We performed mRNA-seq analysis of non-treated and etoposide-treated samples in control and TLP-knockdown cells. We show that TLP is

NIAID Data Ecosystem10

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

inactive NbaSPARDA complexes

蛋白质复合物结构

酶活性机制

inactive NbaSPARDA complexes

NIAID Data Ecosystem20