Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice

In the present study, we developed a stable animal model of drug-induced acute hepatic injury and drug-induced acute hepatic failure with different doses of acetaminophen (APAP, 300 mg/kg APAP and 750 mg/kg APAP) by intraperitoneal injection. We compared hepatic transcriptome profiling between these two models by RNA sequencing (RNA-seq) and tried to further understand the mechanisms of hepatotoxicity influencing the prognosis and seek novel prognostic indicators of DILI.