CD95L derived si- and shRNAs and the CD95L mRNA kill cancer cells through an RNAi mechanism by targeting survival genes [siL3.RNAseq.lg]
收藏NIAID Data Ecosystem2026-04-30 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP111532
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We provide evidence that shRNAs and siRNAs derived from CD95 and CD95L preferentially target the 3' UTRs of survival genes culminating in a very robust mode of cell death we call DISE (Death Induced by Survival gene Elimination) Overall design: RNA isolated from HeyA8 cells 48 hrs after transfection with either a nontargeting siRNA (siScr) or a CD95L derived siRNAs (siL3) were subjected to deep sequencing, using Illumina HiSeq4000.
创建时间：
2022-09-09
