Expression of PAX7 in the neural plate border

Stimulation of WNT signaling in human embryonic stem cells activates expression of PAX7 via beta-catenin (CTNNB1) early (3 days) in the differentiation process (Leung et al. 2016). The TFAP2A:TFAP2C dimer, SOX2, POU5F1 (OCT4), and MYB bind the PAX7 gene and activate its expression in the neural plate border (inferred from chicken homologs). BMP4 (Leung et al. 2016) and FGF4 (inferred from chicken homologs) also activate PAX7 in the neural plate border.

人类胚胎干细胞中WNT信号通路的激活，通过β-连环蛋白（CTNNB1）在分化早期（3天）诱导PAX7基因的表达（参见Leung等，2016年）。TFAP2A:TFAP2C二聚体、SOX2、POU5F1（OCT4）和MYB蛋白结合于PAX7基因，并在神经板边缘激活其表达（根据鸡同源基因推断）。BMP4（参见Leung等，2016年）和FGF4（根据鸡同源基因推断）亦能在神经板边缘激活PAX7基因的表达。