Analysis of differential genes in myocardial hypertrophy mice treated with dapagliflozin. Analysis of differential genes in myocardial hypertrophy mice treated with dapagliflozin

The purpose of this study was to investigate the effect of dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, on relieving cardiac hypertrophy and its potential molecular mechanism. Dapagliflozin activated the Plin5/PPARα signaling axis and exerts a protective effect against cardiac hypertrophy. Overall design: the tissues from HF, HFS and NC group were sujected to total RNA isolation using TRIzol reagent. Then, a microarray analysis was taken to analyze the differential genes.