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Identification, enzymatic and structural characterization of Mycobacterium tuberculosis PNPase (Rv2783c) as novel drug target

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP504020
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The Goal was to look into the specifity of compound X1 against Mtb-complex. Therefore a whole cell assay in M.smegmatis was developed (essential gene swap). Variour M.smegmatis strains were genetically engineered and confirmed by souther Blot analysis and WGS.
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2025-05-01
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