Cell-free DNA as biomarker for sepsis by integration of microbial and host information

We report that blood cell-free DNA as a promising biomarker for the diagnosis of sepsis and for the prediction of 28-day mortality of ICU patients by integrating both human and microbial cfDNA components. Comparison of human cfDNA fragmentation patterns and blood microbial features profiled by cfDNA between septic patients and non-septic ICU patients