PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AZTREONAM-NITROXIDE CONJUGATES
收藏DataCite Commons2026-02-26 更新2026-05-03 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-DC-2363923516
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资源简介：
Bacterial biofilms limit drug penetration and promote bacterial persistence. As quorum sensing regulates biofilm development, its disruption represent a promising strategy to counter antimicrobial resistance. Nitric oxide (NO) disperses biofilms by activating c-di-GMP–degrading phosphodiesterases, and nitroxides act as NO mimics with similar activity. In this study, aztreonam–nitroxide conjugates were developed as dual-action agents against biofilm-forming pathogens. crystal structures of the aztreonam–nitroxide conjugates (15–18) bound to S. pneumoniae PBP1b provide useful insights into the influence of linker length on binding.
提供机构：
European Synchrotron Radiation Facility
创建时间：
2026-02-26
