Efficacy of Topical Lidocaine for Pain Control During Manual Vacuum Aspiration: A Double-Blind, Randomized, Placebo-Controlled Trial

Title: Dataset: "Efficacy of Topical Lidocaine for Pain Control During Manual Vacuum Aspiration" (ENDOLID Trial)

Description: This dataset contains the results of a double-blind, randomized, placebo-controlled clinical trial investigating the efficacy of 10% topical lidocaine spray for pain control during Manual Vacuum Aspiration (MVA). Postmenopausal patients (N=129) diagnosed with endometrial thickening were randomized to receive either topical lidocaine or a saline placebo spray before a standard paracervical block. The primary outcome was pain intensity measured on a Visual Analog Scale (VAS) during the paracervical block injection. Secondary outcomes were VAS scores at four other procedure timepoints.

Data Collection: Pain (VAS) was recorded at five timepoints: 1) paracervical block injection, 2) Pozzi forceps placement, 3) cannula insertion, 4) 2 minutes into aspiration, and 5) 2 hours post-procedure. Sociodemographic and clinical baseline characteristics (age, education, ethnicity, endometrial thickness) were also collected.

Notable Findings: The analysis revealed a statistically significant reduction in mean VAS pain scores during the paracervical block injection for the lidocaine group (6.6 ± 0.98) compared to the placebo group (7.2 ± 0.75; p<0.001). No significant differences were found at any other timepoints. This indicates topical lidocaine is effective specifically for reducing the pain of the initial needle injection but not the subsequent procedural pain.

Interpretation: The data supports the targeted use of topical lidocaine as a simple, low-cost adjunct to improve patient comfort during the administration of paracervical anesthesia for gynecological procedures like MVA.

File Format: The primary data file is saved in SPSS format (.sav) and contains the raw, de-identified data for all 129 participants.