IFN? is a central node in cancer immune equilibrium
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP396035
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资源简介：
The anti-tumor effects of IFN? are well-known as IFN? binding to tumor cells increases antigen presentation and can cause cytostatic growth defects. Indeed, the inability of tumors to respond to IFN? often renders tumors resistant to checkpoint blockade and other immunotherapies reliant on direct T cell cytotoxicity. We demonstrate through RNA-sequencing that IFNgR1-/- and STAT1-/- tumors are defective in their response to IFN? compared to wild-type tumors. Overall design: Wild-type, STAT1-/-, and IFNgR1-/- B16-Nectin1+ cells were cultured in vitro for 24 hours with 0 or 100 ng/ml IFN?. Total RNA was extracted from cells of biological triplicates.
创建时间：
2023-03-09
