CD phenotype stratified by the IVS4+10 A>C variant (rs72796353).

Group (1), 43 CD patients heterozygous for the C allele of the rs72796353 variant and no further main NOD2 mutant, and 2 patients homozygous for the C allele of the rs72796353 variant; group (2), CD patients without the IVS4+10 A>C variant and with no further main NOD2 mutant (NOD2 wild-type). ORs are based on the NOD2 wild-type group (e.g., NOD2 wild-type status is protective against perianal fistulas).
1 Disease behaviour was defined according to the Montreal classification. A stricturing disease phenotype was defined as presence of stenosis without penetrating disease. The diagnosis of stenosis was made surgically, endoscopically, or radiologically (using MR enteroclysis).
2 Immunosuppressive agents included azathioprine, 6-mercaptopurine, methotrexate, infliximab, and/or adalimumab.
3 Only surgery related to CD-specific problems (e.g., ileocecal resection, fistulectomy, colectomy, ileostomy) was included.
CD phenotype stratified by the IVS4+10 A>C variant (rs72796353).