Transition-Metal-Free Regioselective Intermolecular Hydroamination of Conjugated 1,3-Dienes with Heterocyclic Amines
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https://figshare.com/articles/dataset/Transition-Metal-Free_Regioselective_Intermolecular_Hydroamination_of_Conjugated_1_3-Dienes_with_Heterocyclic_Amines/19379772
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资源简介：
The
unique property of hexafluoroisopropanol (HFIP) enables the
regioselective hydroamination of 1,3-dienes with nitrogen heterocycles
in a Markovnikov manner in the presence of catalytic Brønsted
acid. This transition-metal-free intermolecular hydroamination protocol
is achieved under mild reaction conditions. The aggregation by HFIP
and Brønsted acid helps to activate the terminal double bond
regioselectively. Following the protonation of diene, the C–N
bond formation is accomplished upon the involvement of heterocyclic
amines.
创建时间：
2022-03-17
