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Total Synthesis of (±)-Sculponeatin N

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https://figshare.com/articles/dataset/Total_Synthesis_of_Sculponeatin_N/2336611
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The first total synthesis of the (±)-sculponeatin N (a 6,7-seco-ent-kaurane diterpenoid discovered by Sun and co-workers) has been achieved. The features include a regio- and stereoselective aldol reaction to form a lactone, an intramolecular Diels–Alder reaction to install B and C rings simultaneously, and a radical cyclization to forge the D ring.
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2016-02-18
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