Mural cells interact with macrophages in the dural meninges to regulate CNS immune surveillance. Mural cells interact with macrophages in the dural meninges to regulate CNS immune surveillance

We sought to elucidate the cell-cell communication, primarily between pericytes and macrophages, within the dura mater compared to other relevant tissues (leptomeninges and brain) in pre-symptomatic EAE and at the onset of symptoms. Overall design: Pdgfrb-CreER/T2::Rosa-DTR mice were treated with tamoxifen to induce expression of diphtheria toxin receptor (DTR) on PDGFRb+ cells. EAE was induced via MOG immunization and dura mater, leptomeninges, and brain (cortex) isolated 7 or 14 days later.