Cu(II)-based coordination polymers: structural determination and protective effect on myocardial ischemia-reperfusion injury by reducing inflammatory response
收藏Taylor & Francis Group2020-11-20 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Cu_II_-based_coordination_polymers_structural_determination_and_protective_effect_on_myocardial_ischemia-reperfusion_injury_by_reducing_inflammatory_response/12377063
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资源简介：
In this work, two Cu(II)-containing coordination polymers, namely, {[Cu<sub>2</sub>(L)<sub>2</sub>(dpyb)(H<sub>2</sub>O)<sub>4</sub>]·6H<sub>2</sub>O}<sub>n</sub> (<b>1</b>) and {[Cu<sub>2</sub>(L)<sub>2</sub>(dpyb)](CH<sub>3</sub>CN)<sub>2</sub>}<sub>n</sub> (<b>2</b>) have been hydrothermally synthesized based on a substituted thiophene carboxylic acid 3,3′-(thiophene-2,5-diyl)dibenzoic acid (H<sub>2</sub>L) and auxiliary N-donor co-ligand 1,4-di(pyridin-4-yl)benzene (dpyb). Furthermore, the protective effect of compounds <b>1</b> and <b>2</b> on myocardial ischemia-reperfusion injury (MIRI) was evaluated and the specific was explored. The real-time reverse transcription-polymerase chain reaction (RT-PCR) revealed the down-regulated relative expression of the <i>nf-κb</i> and <i>mapk</i> genes after compound treatment. The enzyme-linked immunosorbent assay (ELISA) suggested the inhibitory of the compound on inflammatory cytokines IL1-β and TNF-α releasing.
提供机构：
Fu-Long Bi; Ri-Song Na
创建时间：
2020-05-27
