Logistic regression analysis to look for effect of mothers' alleles at ABCA4 and COL2A1 on clinical outcome in children in the EMSCOT cohort who became infected in utero.

SNP = single nucleotide polymorphism; OR = odds ratio; CI = 95% confidence intervals; P = probability. Data shown only for markers were PTable 1) or mothers' alleles, P��0.05 is shown in bold. All analyses for the EMSCOT study were adjusted for country of birth, trimester of seroconversion, and country of origin of grandparents as a surrogate for ethnicity.aDetails of allele frequencies provided in Table S1.bPhenotypes of children infected in utero from mothers infected during pregnancy.cSignificant allele-wise associations were also observed at ABCA4 rs1761375 and rs952499 for mothers of children with brain lesions but not eye lesions (data not shown). None of the COL2A1 associations in EMSCOT were significant when the analysis was stratified for mothers of children with brain lesions (data not shown). Table S8 provides full details of the numbers of mothers carrying each genotype for each phenotypic group.