Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites.
收藏PubMed Central1992-12-01 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC50592/
下载链接
链接失效反馈官方服务：
资源简介：
The DNA-binding activity of c-Jun expressed in eukaryotic cells was found to be markedly enhanced if the intracellular concentration of binding sites for this transcription factor was increased by cotransfection of specific plasmid DNA. Dephosphorylation experiments, phosphate mapping studies, and mutational analysis indicate that phosphorylation of a cluster of serine and threonine residues situated in close proximity to the DNA-binding domain is responsible for the observed adaptation of c-Jun activity to the intracellular concentration of accessible target sites. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-12-01
