DNA methylome profiling of blood to identify individuals in a pair of monozygotic twins. DNA methylome profiling of blood to identify individuals in a pair of monozygotic twins

Short tandem repeat (STR) markers cannot be used to distinguish between genetically identical monozygotic (MZ) twins, causing problems in a case with an MZ twin as a suspect. Many studies have shown that in older MZ twins, there are significant differences in overall content and genomic distribution of methylation Overall design: Bisulphite converted DNA from the 94 samples were hybridised to the Illumina Infinium 850k Human Methylation Beadchip