Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions (WGBS 2)

Investigation into changes in the methylome in rapamycin and caloric restriction in aged mice. Examination of methylation states via high-throughput, whole-genome bisulfite sequencing in mouse hepatocytes of young (2 month) and aged (22 month) mice that display increased longevity through a variety of interventions