Competition-based fitness assays in Cas9-expressing PDAC cell lines after CRISPR-Cas9 knockout (KO) of KLF5 or ROSA26 (control) using sgRNAs coupled to GFP. Data shown as mean ± SD of no

DataCite Commons2025-10-10 更新30

Characterisation_of_checkpoint_deficient_tumours_to_identify_alterations_that_allow_survival_of_chromosomal_instable_cells

染色体不稳定性

癌细胞适应性

Aneuploidy and chromsomal nistability are hallmarks of tumors. We have generated mouse models in which we can induce chromosomal instability by abrogating the sopindle checkpoint in a tissue of choice

NIAID Data Ecosystem20

Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species

线粒体代谢

癌细胞适应性

Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of cancer cells. The mechanism by which mitochondrial metabolism regulates mROS levels

NIAID Data Ecosystem40

Hypoxic transcriptomic signature of A549 cells (Agilent microarrays). Hypoxic transcriptomic signature of A549 cells (Agilent microarrays)

癌细胞转录组

癌细胞适应性

To assess the transcriptomic response of the LUAD cell line A549 to hypoxia, cells were exposed to 1% (Hx) or 21% O2 (Nx) during 24 hours. Two independent experiments were carried out. Overall design:

NIAID Data Ecosystem20

Phenotypic and epigenetic adaptations of cord blood CD4+ T cells to maternal pregravid obesity.

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