Concentrations of total 2G12 and 2G12 dimer (average ± s.e.m.) in backpacked mice.
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Plasma concentrations of 2G12 (Total) were measured by ELISA. 2G12 dimer and 2G12 monomer concentrations were then calculated as described in the text and Materials and Methods. Concentrations of total 2G12 and 2G12 dimer are shown; the concentration of 2G12 monomer for each condition is obtained by subtracting the dimer concentration from the concentration of total 2G12. BP, backpacks. BP, large backpacks that yield high concentrations of 2G12. Ganciclovir was injected to control the size of the backpacks below 1.5 cm2.
aAUC: area under the curve from week 0 to week 4.
bSignificant difference in total 2G12 concentration between D2 BP and 2G12 BP. Mann-Whitney tests showed that the p values for week 0, 1, 3 were 0.0256, 0.0228, 0.0221, respectively.
cSignificant difference in AUC of total 2G12 between D2 BP and 2G12 BP (Mann-Whitney test; p = 0.0411).
dSignificant difference in 2G12 dimer concentration between D2 BP and 2G12 BP. Mann-Whitney tests showed that the p values for week 0, 1, 2, 3 were 0.0198, 0.0084, 0.0197, 0.014, respectively.
eSignificant difference in AUC of 2G12 dimer between D2 BP and 2G12 BP (Mann-Whitney test; p = 0.0047).
创建时间：
2010-12-16
