Activated PPARG binds PTEN gene promoter

The nuclear receptor PPARG (PPARgamma), activated by ligand binding, binds to peroxisome proliferator response elements (PPREs) in the promoter of the PTEN gene to activate PTEN transcription. It has not been tested whether nuclear receptors that heterodimerize with PPARG are involved in transcriptional regulation of PTEN (Patel et al. 2001).

核受体PPARG（PPARgamma）在配体结合激活后，与PTEN基因启动子中的过氧化物酶体增殖因子反应元件（PPREs）结合，以激活PTEN的转录。尚未测试与PPARG异源二聚化的核受体是否参与PTEN（Patel等，2001年）转录调控。