Translocation of BBC3 (PUMA) protein to mitochondria
收藏reactome.org2025-03-25 收录
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It is thought that due to its p53 dependence for expression, PUMA could function as a mediator of p53-induced apoptosis. Newly synthesized PUMA protein translocates to mitochondria and binds to BCL-2 and Bcl-X(L) through a BH3 domain.
鉴于PUMA的表达依赖于p53，有观点认为PUMA可能充当p53诱导的细胞凋亡的介导因子。新合成的PUMA蛋白通过BH3结构域转移至线粒体，并与BCL-2及Bcl-X(L)结合。
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