Estrogen signaling

Estrogen receptor refers to a group of receptors which are activated by the hormone 17-beta-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC Assay Portal]

雌激素受体是指一类受激素17-β-雌二醇（雌激素）激活的受体。雌激素受体存在两种类型：ER，它是细胞内核激素受体家族的成员，以及雌激素G蛋白偶联受体GPR30（GPER），它是一种G蛋白偶联受体。雌激素受体的主要功能是作为DNA结合转录因子，调控基因表达。然而，雌激素受体还具有与DNA结合无关的附加功能。该通路上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP712 CPTAC检测门户]进行目标检测。