Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor
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Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor Descriptor: 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide, Serine/threonine-protein kinase B-raf Authors: Yano, J.K, Aertgeerts, K. Deposit date: 2012-05-23 Release date: 2014-01-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives. Bioorg.Med.Chem., 20, 2012
创建时间：
2012-05-23
