Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT

This dataset contains GWAS meta-analysis summary statistics for serum iron, serum ferritin, transferrin saturation and total iron binding capacity. Iron is essential for many biological processes, but iron levels must be tightly regulated to avoid harmful effects of both iron deficiency and overload. Here, we perform genome-wide association studies on four iron related biomarkers (serum iron, serum ferritin, transferrin saturation, total iron binding capacity) in the Trøndelag Health Study (HUNT), the Michigan Genomics Initiative (MGI) and the SardiNIA study, followed by their meta-analysis with publicly available summary statistics, analyzing up to 257,953 individuals.

本数据集收录了血清铁、血清铁蛋白、转铁蛋白饱和度和总铁结合力的全基因组关联分析（GWAS）元分析汇总统计量。铁是众多生物学过程中的关键元素，但其水平必须严格调控，以避免铁缺乏和铁超载的潜在有害影响。在本研究中，我们对特伦德尔اغ健康研究（HUNT）、密歇根基因组计划（MGI）和萨迪尼亚研究（SardiNIA）中的四个与铁相关的生物标志物（血清铁、血清铁蛋白、转铁蛋白饱和度、总铁结合力）进行了全基因组关联研究，并对其与公开可用的汇总统计量进行了元分析，涉及个体数量高达257,953名。