Comparing protein-coding and noncoding genic intolerance scores.

To enable a matched comparison, the estimates in this table are based on a set of 14,567 CCDS genes with assessable scores across RVIS-CHGV, ncRVIS and ncGERP formulations. Both RVIS-CHGV and ncRVIS are based on the same population of 690 whole-genome sequenced samples from the CHGV.aHI = Haploinsufficiency. To obtain the presented levels of significance, we used a logistic regression model to regress the presence or absence of a gene within the corresponding gene list on each of the genic scores.Joint Model: The AUC of a combined logistic regression model that uses all three features. Correlation plots for the pairs of scores are available in S1 Fig.Comparing protein-coding and noncoding genic intolerance scores.