Human Myelinated Brain Assembloids: A Novel Platform for Investigating Mechanisms and Enhancement of Remyelination

We created a human brain model to study the breakdown and repair of myelin, a process critical in neurological disorders. This system allows for the investigation of myelin dynamics and the testing of potential treatments. Overall design: Myelinated brain organoids with and without integrated microglia which were either untreated, or demyelinated or remyelination