RNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD1

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease caused by loss of motor neurons. SOD1 may have a toxic role in the pathogenesis of ALS when the protein aggregates in the cytoplasm; increased accumulation of soluble nuclear SOD1 (nSOD1) represents a protective cellular reaction. Overall design: Peripheral Blood Mononuclear Cells derived from 18 sALS patients and 12 age- and sex-matched healthy controls (CTRL) were deep-sequenced and included in Real Time PCR experiments.