Asymmetric Synthesis of Spiro-epoxyoxindoles by the Catalytic Darzens Reaction of Isatins with Phenacyl Bromides
收藏NIAID Data Ecosystem2026-03-08 收录
下载链接：
https://figshare.com/articles/dataset/Asymmetric_Synthesis_of_Spiro_epoxyoxindoles_by_the_Catalytic_Darzens_Reaction_of_Isatins_with_Phenacyl_Bromides/2264326
下载链接
链接失效反馈官方服务：
资源简介：
The asymmetric Darzens reaction between
phenacyl bromides and N-protected isatins was developed
to synthesize potentially bioactive spiro-epoxyoxindoles. The
optically active products were obtained in moderate to good yields
and enantioselectivities catalyzed by chiral N,N′-dioxide-Co(acac)2 complexes.
A retro-aldol process accompanying the ring-closure step was observed
in the process. A chiral control step was determined to be the initial
aldol addition.
创建时间：
2016-02-17
