RNA sequencing results of cell migration and adhesion induced by modulated expression of paraspeckle protein PSPC1

We found that PSPC1 potent facilitates HCC cells motility, adhesion, cytoskeleton assembling as well as cell spreading. To elucidate underlying mechanisms regulation by PSPC1, we performed the RNA-seq analysis of overexpression of PSPC1 in SK-Hep1 cell line and knockdown od PSPC1 in Hep3B cell line to evaluate its effects on gene expression. Gene expression profiles of PSPC1 with modulated knockdown in Hep3B cells were generated by Illumna RNA sequencing and compared to profiles derived from mock control cells.