The Neurodegenerative Rescue Manifold v1.4: Multi-Scale Structural Mapping and Lead Scaffolds for Reversing Nucleation in ALS, Alzheimer's, and Huntington's Disease

The Neurodegenerative Rescue Manifold v1.4: Multi-Scale Structural Mapping and Lead Scaffolds for Reversing Nucleation in ALS, Alzheimer's, and Huntington's Disease This deposition provides the definitive structural mapping and therapeutic blueprint for reversing pathogenic protein nucleation across the neurodegenerative spectrum. Developed within the Nexus Resonance Codex (NRC) framework, this manifold utilizes HDR-512 high-dimensional lattice resonance to identify "Structural Rescue Pockets" in SOD1, TDP-43, and Tau proteins. Key Research Components: ALS/SOD1 Stabilization: Atomic-level mapping of the A4V mutant and lead scaffolds for structural stabilization. - Alzheimer's/Tau Resonance: Multi-scale analysis of Tau aggregation kinetics and inhibitory resonant frequencies. - Huntington's Disease: Scaffolds designed for polyglutamine nucleation reversal. - Clinical Protocol: A complete Phase 0 translational framework for NRC-derived neuro-therapeutics. Professional Context & Links: GitHub Repository: https://github.com/jtrag/Protein-Folding - NRC Framework: https://github.com/jtrag/Nexus-Resonance-Codex - Researcher Profile: https://x.com/jtrag | https://orcid.org/0009-0006-6678-2908 - Cross-Manifold Reference: See also the Pediatric Rescue Manifold (https://zenodo.org/records/19777357) for related structural rescue logic. Nexus Resonance Codex (NRC) - Phase 5 Strategic Release.