ALK upregulates POSTN and WNT signaling to drive neuroblastoma

The goal of this study is to identify the mechanism for how ALK promotes tumorigenesis in neuroblastoma. We developed a human stem cell model of neuroblastoma and generated isogenic tumors using MYCN and MYCN/ALK. RNAseq analysis of both tumors revealed an enrichment in focal adhesion signaling and allowed us to find POSTN as a key mediator of ALK-mediated tumor growth. Overall design: The samples are human stem cell derived trunk neural crest cells that were implanted into mice and developed into tumors. We have samples of WTC11 MYCN, WTC11 MYCN/ALK and 1323 MYCN tumors. The data provided is RNA-seq analysis of each of the samples in triplicate