BIOGRID CURATED DATA FOR SEC62 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for SEC62 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p

由 BioGRID (https://thebiogrid.org) 精心编纂的 SEC62（酿酒酵母 S288c）蛋白质-蛋白质、遗传和化学相互作用数据集；定义：Sec63 复合物不可或缺的亚基；与 Sec61 复合物、Kar2p/BiP 和 Lhs1p 共同构成一个通道，该通道能够进行 SRP 依赖性和翻译后 SRP 非依赖性蛋白质靶向以及进入内质网的转运；在翻译过程中由 NatA 进行 N-乙酰化；其他成员包括 Sec63p、Sec66p 和 Sec72p。