Gut biopsies from patients with Crohn's Disease and Ulcerative Colitis and healthy controls

For IBD, >163 susceptibility loci have been revealed by Genome-wide association studies (GWAS). Still only 13.6% of the heritability in CD and 7.5% in UC can be explained by the loci that have been revealed (23128233). In an endeavor to pinpoint additional IBD genes and pathways involved in the disease, we have made a large scale transcriptome analysis of human pince 380 biopsies from 109 donors. We identified novel genes and protein-protein interaction networks that are strongly associated with disease and gives new insight to the pathology of both CD and UC and the resulting inflammation Cross-sectional sample collection from patient