BIOGRID CURATED DATA FOR TMA17 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for TMA17 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: ATPase dedicated chaperone that adapts proteasome assembly to stress; Tma17p is induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion

蛋白质-蛋白质、遗传和化学相互作用数据集，针对TMA17（酿酒酵母S288c）由BioGRID（https://thebiogrid.org）整理；定义：专一性ATP酶辅助蛋白，能够适应蛋白酶体组装以应对压力；Tma17p在压力条件下被诱导；与Rpt6p相互作用，协助其与Rpt3p配对以及蛋白酶体生物发生早期步骤；与核糖体相关联；在rad9缺失背景下，同源删除实验表明染色体不稳定性增加；细胞内铁缺乏时，蛋白质丰度降低。