Transcriptomic analysis of mouse subcutaneous tumor after intratumoral treatment with SLR14 or vehicle. Transcriptomic analysis of mouse subcutaneous tumor after intratumoral treatment with SLR14 or vehicle

We subcutaneously injected 5x105 YUMMER1.7 melanoma into right flank of C57BL/6J mice. 7 days later, the mice were intratumorally treated with 1 mg/kg SLR14 or vehicle every 3 days, for a total of 3 cycles. We observed a significant tumor growth delay in SLR14-treated mice compared to vehicle-treated mice. Overall design: The tumors were intratumorally treated with 1 mg/kg SLR14 or vehicle. After 3 cycles of treatment, tumors were harvested and total RNAs were extraced.