Saturated Long Chain Fatty Acid-Producing Bacteria Contribute to Enhanced Colonic Motility in Neonatal Maternal Separated Rats. rat gut metagenome

The gut microbiota is closely associated with gastrointestinal (GI) motility disorder, but the mechanism by which bacteria interact with and affect host GI motility remains unclear. In this study, an animal model of neonatal maternal separation (NMS) characterized by accelerated colonic motility and gut dysbiosis was used to investigate the mechanism underlying microbiota-driven motility dysfunction. Here we performed fecal metabolomic and metagenomic analyses to clarify the linkage between gut microbiota and host colonic motility phenotype, and to capture which bacteria are the main manipulators for host GI colonic dysmotility.