Lineages and sublineages of human papillomavirus type 16 in cervical samples of Iranian women: supplementary data

Aim: This study was designed to analyze intratypic variations of human papillomavirus type 16 (HPV16)
and to assess the risk of these variants for progression to cervical cancer. Materials & Methods: HPV16
variants of 58 women were determined by PCR-directed sequencing. Results: The most frequent lineage
was D (67.2%) followed by A (32.8%). Lineage A was found predominantly in normal (62.5%) and cervical
intraepithelial neoplasia-1 (CIN-1) (83.3%), while lineage D was the most prevalent variant in cervical
cancer (100%). Conclusion: The present study revealed a distinct pattern of HPV16 variants in Iran. Based
on our data, the predominant HPV16 lineage was D and there was a significant association between
lineage D variants and cervical cancer.