Sequential maturation of stimulus-specific adaptation in the mouse lemniscal auditory system

Stimulus-specific adaptation (SSA), the reduction of neural activity to a common stimulus that does not generalize to other, rare stimuli, is an essential property of our brain. Although well characterized in adults, it is still unknown how it develops during adolescence and what neuronal circuits are involved. Using in vivo electrophysiology and optogenetics in the lemniscal pathway of the mouse auditory system, we observed SSA to be stable from postnatal day 20 (P20) in the inferior colliculus, to develop until P30 in the auditory thalamus (MGV) and even later in the primary auditory cortex (A1). We found this maturation process to be experience-dependent in A1 but not in MGV, and to be related to alterations in deep but not input layers of A1. We also identified corticothalamic projections to be implicated in MGV SSA development. Together, our results reveal different circuits underlying the sequential SSA maturation and provide a unique perspective to understand predictive coding an..., The data was collected using in vivo electrophysiological recordings in awake mice, using Neuronexus multishaft electrodes (A64 or A32). It was then processed for spike sorting using kilosort1, and curated manually using phy. Further details are described in the manuscript., , # Sequential maturation of stimulus-specific adaptation in the mouse lemniscal auditory system.

Give a brief summary of dataset contents, contextualized in experimental procedures and results.

## Description of the data and file structure

The files are organized by figures. For each file, all data used in the figure panels for plotting averages or distributions across units are represented, with each row/cell representing the value described in this panel for one single unit. The only exception is for Figure 2A, where a cell represents the average of the whole population at a given tone presentation, as displayed on the corresponding graphs.

Prefixes and abbreviations used across datasets:

-        P#: Postnatal age of the mice studied in number of days form birth (example: P20: 20 day old mouse)
-        SSA: stimulus specific adaptation
-        CSI: common SSA index
-        ICC: central nucleus of the inferior colliculus
-        MGV: ventral part of the medial geniculate bod...