Access to α,α-Disubstituted Disilylated Amino Acids and Their Use in Solid-Phase Peptide Synthesis

A concise synthetic pathway yielding
to hydrophobic α,α-disubstituted
disilylated amino acids based on a hydrosilylation reaction is described.
As a first example of utilization in solid-phase peptide synthesis,
TESDpg was introduced in replacement of Aib in an alamethicin sequence,
leading to analogues with modified physicochemical properties and
conserved helical structures. This study highlights the potential
of these new amino acids as tools for peptide modulation.