Electrocardiographic Findings in Brazilian Adults without Heart Disease: ELSA-Brasil

Abstract Background: The electrocardiogram (ECG) is widely used in population-based studies. However, there are few studies on electrocardiographic findings in Latin America and in Brazil. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) comprised 15,105 participants (35-74 years) from six Brazilian capitals. Objectives: To describe electrocardiographic findings in Brazilian adults without heart disease, stratified by sex, age and race/skin color. Methods: Cross-sectional study with baseline data of 11,094 adults (44.5% men) without heart disease from ELSA-Brasil. The ECGs were recorded with the Burdick Atria 6100 machine and stored at the Pyramis System. ECG analysis was automatically performed using the Glasgow University software. A descriptive analysis of heart rate (HR), P, QRS and T waves’ duration, PR and QT intervals, and P, R and T axes was performed. After stratification by sex, race/color and age, the groups were compared by the Wilcoxon and Kruskal-Wallis test at a significance level of 5%. Linear regression models were used to evaluate the behavior of electrocardiographic parameters over age. Major electrocardiographic abnormalities defined by the Minnesota code were manually revised. Results: Medians values of the electrocardiographic parameters were different between men and women: HR 63 vs. 66 bpm, PR 164 vs.158 ms, QT corrected 410 vs. 421 ms, QRS duration 92 vs. 86 ms, P-wave duration 112 vs. 108 ms, P-wave axis 54 vs. 57 degrees, R-wave axis 35 vs. 39 degrees, T-wave axis 39 vs. 45 degrees (p < 0.001 for all). The 2nd and the 98th percentiles of each variable were also obtained, and graphs were constructed to illustrate the behavior of the electrocardiographic findings over age of participants stratified by sex and race/skin color. Conclusions: The values for the electrocardiographic measurements herein described can be used as reference for Brazilian adults free of heart disease, stratified by sex. Our results suggest that self-reported race/skin color have no significant influence on electrocardiographic parameters.

研究背景：心电图（electrocardiogram, ECG）广泛应用于人群队列研究，但目前针对拉丁美洲及巴西人群的心电图表现相关研究较为匮乏。巴西成人健康纵向研究（Brazilian Longitudinal Study of Adult Health, ELSA-Brasil）纳入了来自巴西6个首府的15105名年龄在35~74岁之间的参与者。研究目的：描述巴西无心脏疾病成人的心电图表现，并按性别、年龄及种族/肤色进行分层分析。研究方法：本研究为横断面研究，使用ELSA-Brasil队列的基线数据，纳入11094名无心脏疾病的成人受试者，其中男性占比44.5%。心电图记录采用Burdick Atria 6100设备完成，数据存储于Pyramis系统；心电图分析通过格拉斯哥大学开发的软件自动完成。本研究对心率（heart rate, HR）、P波、QRS波、T波时限，PR间期、QT间期，以及P波、R波、T波电轴开展描述性分析。按性别、种族/肤色及年龄分层后，采用Wilcoxon检验与Kruskal-Wallis检验进行组间比较，检验水准设定为5%；同时使用线性回归模型评估心电图参数随年龄的变化趋势。由明尼苏达编码（Minnesota code）定义的主要心电图异常均经过人工复核。研究结果：男性与女性的心电图参数中位数存在显著差异：心率分别为63次/分钟与66次/分钟，PR间期分别为164ms与158ms，校正QT间期分别为410ms与421ms，QRS波时限分别为92ms与86ms，P波时限分别为112ms与108ms，P波电轴分别为54°与57°，R波电轴分别为35°与39°，T波电轴分别为39°与45°（所有指标P<0.001）。本研究同时获取了各变量的第2百分位数与第98百分位数，并绘制图表以展示按性别及种族/肤色分层的受试者心电图表现随年龄的变化趋势。研究结论：本研究描述的心电图测量值可作为巴西无心脏疾病成人（按性别分层）的参考标准。本研究结果提示，自我报告的种族/肤色对心电图参数无显著影响。

搜集汇总

背景与挑战

背景概述

该数据集基于巴西成人健康纵向研究（ELSA-Brasil），包含11,094名无心脏病的巴西成年人（年龄35-74岁）的心电图数据，旨在提供按性别、年龄和种族/肤色分层的心电图参数参考值。研究结果显示，心电图参数在男性和女性之间存在显著差异，例如心率、PR间期和QRS持续时间等，但自我报告的种族/肤色对参数无显著影响。这些发现可作为巴西无心脏病成年人群的心电图基准数据，适用于流行病学和临床研究。