Spatial Transcriptomics Identifies Cytotoxic and Fibrotic Immune-Stromal Niches in Morphea and Eosinophilic Fasciitis

This dataset contains raw Xenium Prime 5K (10X Genomics) spatial transcriptomic outputs from human skin biopsies from patients with morphea and eosinophilic fasciitis (EF). Included samples:- M1: Morphea, plaque subtype, left breast- M2: Morphea, generalized subtype, left chest- EF1: Eosinophilic fasciitis, left upper thigh- EF2: Eosinophilic fasciitis, left forearm All tissue was formalin-fixed paraffin-embedded (FFPE) and analyzed using the Xenium Prime 5K Human Pan-Tissue and Pathways panel with a 100-gene add-on. Each ZIP archive contains the original Xenium output directory, including:- transcript coordinates- segmentation boundaries- feature matrices- Xenium automated analysis outputs Associated manuscript:"Spatial Transcriptomics Identifies Cytotoxic and Fibrotic Immune-Stromal Niches in Morphea and Eosinophilic Fasciitis"