Copy-number profiling by SNP array of 4 acute myeloid leukemia (AML) cell lines
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138438
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资源简介：
DNMT inhibitors (DNMTi) are finally approved for AML/MDS, also based on their activity in patients with high-risk cytogenetics (often monosomal karyotype) such as -5/del(5q) or -7/del(7q), often - but not always - harboring TP53-mutations. Several studies provided evidence for aberrant hypermethylation/silencing on monoallelic gene loci, including tumor suppressor genes. We hypothesized that transcriptional repression on monosomal gene loci may be preferentially reversed by DNMTi. Using an unbiased RNA-seq approach we aimed to identify preferentially regulated genes in cells monoallelic for chromosome 7q. Affymetrix SNP arrays were performed according to the manufacturer's protocol on DNA extracted from the cultured AML cell lines UCSD-AML1, ELF-153, KG-1 and U937.
创建时间：
2021-03-11
