SCimilarity Human Tissue Atlases

SCimilarity is a unifying representation of single-cell expression profiles that quantifies similarity between expression states and generalizes to represent new studies without additional training. This enables a novel cell search capability, which sifts through millions of profiles to find cells similar to a query cell state and allows researchers to quickly and systematically leverage massive public scRNA-seq atlases to learn about a cell state of interest. This repository provided the SCimilarity reference database of human in vivo scRNA-seq tissue data. This reference is provided as a collection of compressed h5ad files for 30 human organ systems and tissues, with their processed metadata and SCimilarity embedding. This collection was prepared using v1.1 of the SCimilarity model and v0.4.0 of the SCimilarity API. For questions about data availability and terms of use contact Graham Heimberg ([e-mail]) and Jason Vander Heiden ([e-mail]).