The various functions assigned to nsSNPs in each set.

‘Site’ refers to residue specific annotations made by depositors of PDB structures, ‘Ligand’ refers to residues involved in binding a ligand, ‘Metal’ refers to residues coordinating with metals and ‘Catalytic’ to residues involved in the catalytic activity of the protein. The % of non-redundant assigned residues that are ‘functional’ is also shown.