HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.
收藏PubMed Central1991-10-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC52618/
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资源简介：
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-10-15
