Commensal microbiome dysbiosis in keloid disease

Wound healing is an intensely studied topic involved in many relevant
pathophysiological processes, including fibrosis. Despite the large
interest in fibrosis, the network that related to commensal microbiota and
skin fibrosis remain mysterious. Here, we pay attention to keloid, a
classical yet intractable skin fibrotic disease to establish the
association between commensal microbiota to scaring tissue. Our
histological data reveal the presence of microbiota in the keloids. 16S
rRNA sequencing characterize microbial composition and divergence between
the pathological and normal skin tissue. Our research provides insights
into the pathology of human fibrotic diseases, advocating commensal
bacteria and IL-8 signaling as useful targets in future interventions of
recurrent keloid disease.